TWO men have been arrested after a two-vehicle crash at midnight left a man in his 40s from Oxfordshire with life-threatening injuries.

A black Audi estate and a silver Vauxhall Corsa collided at the B4009 Watlington Road, between the M40 J6 and The Fat Fox Inn at Watlington, around 12:05am.

The driver and and the only occupant of the Vauxhall Corsa was taken to the John Radcliffe Hospital where he remains in a critical condition.

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One man from the Audi was taken to the hospital with a leg injury where he remains in a stable condition, while another remains for observation.

A further man did not require hospital treatment, and a woman - believed to be a passenger in the Audi - has not been accounted for as it is believed she walked away from the accident.

Her condition at this time is not known.

Police officers have now arrested a 39-year-old man from Watlington and a 38-year-old man from Glasgow, both on suspicion of causing serious injury by dangerous driving.

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Thames Valley Police is now appealing for witnesses of the incident who can help the investigation.

Senior Investigating Officer, Sergeant Matthew Cadmore said: "This was a serious injury collision which has left one man with life-threatening injuries.

"We are conducting an investigation into this incident and as such we are appealing for witnesses to the collision to come forward.

"We are asking anyone who may have witnessed this collision or seen either of the vehicle travelling to the incident to please come forward.

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"Additionally if you may have been driving on Watlington Road, at around the time of the incident and have dash-cam footage we would ask you to please review that footage and get in touch if you feel it could assist our investigation.

"We are also appealing for the woman who we believe was a passenger in the vehicle who walked away from the scene to please come forward."

Anyone with information should call 101 or go online quoting reference 19 11/7/20.

Members of the public who wish to remain anonymous can call the independent charity Crimestoppers on 0800 555 111.