Commuters may need to find alternate routes home as there are delays of up to 40 minutes on Southeastern services.
An earlier signalling problem between Charlton and Cannon Street is causing delays between Dartford and Cannon Street.
Tickets are being accepted on London Underground, London Overground and DLR services.
Trains between Charlton and London Cannon Street are being diverted via Lewisham and will not stop at Westcombe Park, Maze Hill, Greenwich and Deptford.
Some trains are also being diverted into London Blackfriars or London Victoria.
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