A 31-year-old woman has been stabbed to death at a home in Hither Green.
Police were called to an address in Manor Park at 11.15pm and forced entry into the property.
A 31-year-old woman was found injured inside the property,
She died at the scene shortly after.
A 24-year-old man has been arrested on suspicion of murder at a different address in the nearby area.
He remains in custody.
A crime scene currently remains in place, with police officers and forensics at the scene.
Detective Chief Inspector Mike Nolan, who is leading the investigation, said: “We know people will be shocked by this incident and I would like to reassure the community that we are not looking for anyone else in connection with this investigation."
People living in the area will see an increased policing presence over the coming days.
Chief Superintendent Louise Sargent, responsible for local policing in Lewisham, said: "Tragically overnight a woman has been killed and we do not underestimate the impact this has on the local community and those who knew the victim.
"All of our thoughts are with the victim’s family and friends as we do everything we can to support detectives as they go about their enquiries.
"Please do speak with officers if you need to or contact your local policing team."
A London Ambulance Service spokesperson said: “We were called at 11:09 last night (March 20) to reports of an assault on Manor Park, SE13.
“We sent resources to the scene, including ambulance crews, a paramedic in a fast response car, and an incident response officer. We also dispatched a trauma team from London’s Air Ambulance by car.
“Sadly, a person was pronounced dead at the scene.”
Anyone who with information relating to this incident should call police on 101 quoting the reference 8153/20MAR.
To remain anonymous contact the independent charity Crimestoppers on 0800 555 111.
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