Trains running through Erith, Plumstead and Woolwich Arsenal will not be running at a normal service this Sunday, March 25.
Engineering work between Dartford and Greenwich is set to affect the line all day.
As Network Rail completes the work, several lines will not be running at all.
Trains from Cannon Street to Plumstead via Greenwich and Abbey Wood will be suspended, and several other lines will be diverted.
Bus replacement services will be running between Lewisham and Dartford.
Passengers are advised to plan their journeys ahead of time.
More information can be found on the Southeastern website.
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