Temporary footpath and bus stop closures have been put in place as works continue on the Lewisham Gateway regeneration scheme.
Bus stops C and D outside Lewisham DLR Station were suspended from 9pm on Thursday.
Services are being rerouted to stops H and J on Lewisham High Street outside the police station.
The section of pavement between the southern part of Station Road/Loampit Vale junction and the southern end of Lewisham Road is now closed to pedestrians.
Alternative pedestrian routes have been signposted.
The temporary taxi rank, which was located alongside the DLR Station, has been moved to the newly constructed eastern section of Station Road.
The changes will last until early 2016 with the road layout for Lewisham Gateway expected to be completed in the Spring.
For more details on the Lewisham Gateway project, which will provide new homes, jobs, shops and eateries at http://newlewisham.com/.
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