The Woolwich Road roundabout is the only south east London junction set for improvements as part of a £300m project by the Mayor of London.
In all, 33 of London's biggest road junctions are set to be made safer and less threatening for cyclists in the project.
Details have not been released yet of what changes could be made to the roundabout, which lies at the flyover, links Woolwich Road with the Blackwall Tunnel Approach, and was the scene of a fatal accident in May 2009 when cyclist Adrianna Skryzypiec was killed by a lorry.
Designs for the first schemes will be published next month and work will begin in the second half of this year.Boris Johnson said: "These road junctions are relics of the 60s which blight and menace whole neighbourhoods.
"Like so much from that era, they’re also atrociously-designed and wasteful of space. Because of that, we can turn these junctions into more civilised places for cyclists and pedestrians, while at the same time maintaining their traffic function."